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Patient-derived Models of Asian Cancers (PMAC)

Patient-derived tumor models are valuable tools for cancer research, and may particularly useful for pharmaceutical research and drug development. The Cancer Discovery Hub at the National Cancer Centre Singapore hosts a large catalogue of various tumor models ranging from xenografts to cell-lines, mostly derived from patients of Asian ethnicity. Novel models including organoids are also available for customised purposes.

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All models listed have been verified histopathologically. Additional verification with genomic profiling have been performed for selected models.

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These models are property of contributing research groups, including:

  • Cancer Discovery Hub, NCCS

  • Laboratory of Molecular Endocrinology, NCCS

  • Laboratory of Cancer Epigenome, NCCS

  • Lymphoma Translational Genomics Laboratory, NCCS

  • Laboratory of Applied Human Genetics, NCCS

  • VIVA-KKH Paediatric Solid Tumour Research Laboratory

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Contact us if you are interested to use these models for pharmacological drug evaluation, research collaboration, or if you woud like to contribute your tumor models in this catalogue.

Patient-derived xenografts (PDX)

CARCINOMA

  • Hepatocellular carcinoma: >110 models

  • Gastric carcinoma: 34 models

  • Ovarian carcinoma: 35 models including serous, clear cell, mucinous, endometrioid and others

  • Renal cell carcinoma: 18 models including clear cell, papillary and others

  • Lung carcinoma: 8 models including small cell carcinoma and adenocarcinoma

  • Colorectal carcinoma: 8 models

  • Pancreatic carcinoma: 7 models

  • Breast carcinoma: 4 models

 

LYMPHOMA

  • Natural Killer/T-cell lymphoma (NKTCL)

  • Peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS)

  • Monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL)

  • Diffuse large B-cell lymphoma, non-germinal centre (DLBCL)

  • Mantle cell lymphoma, blastoid variant (MCL)

  • Angioimmunoblastic T-cell lymphoma (AITL)

 

SARCOMA & RARE CANCERS

  • Gastrointestinal stromal tumor: 2 models

  • Malignant phyllodes tumor: 4 models

  • Fibrosarcoma

  • Ewing sarcoma

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ASCITES-DEPENDENT XENOGRAFTS

  • Colorectal carcinoma: 5 models

  • Ovarian carcinoma: 2 models

  • Melanoma

  • Mesothelioma

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PAEDIATRIC CANCERS

  • Neuroblastoma

  • Wilms tumor and renal sarcomas

  • Hepatoblastoma

  • Rhabdomyosarcoma and non-rhabdomyosarcoma soft tissue sarcomas (NRSTS)

  • Osteosarcoma

  • Germ cell tumor and sex cord stromal tumors

Patient-derived cell-lines (PDC)

CARCINOMA

  • Renal cell carcinoma, clear cell: >10 models

  • Renal cell carcinoma, papillary

  • Colorectal carcinoma: > 5 models

  • Ovarian carcinoma: 2 models

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LYMPHOMA

  • Natural Killer/T-cell lymphoma (NKTCL)

  • Anaplastic Large cell lymphoma (ALCL)

  • Cutaneous T-cell lymphoma (CTCL)

  • Peripheral T-cell lymphoma, NOS (PTCL-NOS)

  • Diffuse large B-cell lymphoma (DLBCL)

  • Burkitt lymphoma (BL)

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SARCOMA & RARE CANCERS

  • Malignant phyllodes tumor: 5 models

  • Angiosarcoma: 3 models

  • Gastrointestinal stromal tumor: 2 models

  • Dermatofibrosarcoma protuberans/fibrosarcoma (DFSP/FS)

  • Solitary fibrous tumor (SFT)

  • Leiomyosarcoma (LMS)

  • Undifferentiated pleomorphic sarcoma (UPS)

  • Myxofibrosarcoma

  • Mesothelioma: 2 models

  • Melanoma

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PAEDIATRIC BRAIN TUMORS

  • Glioma

  • Embryonal tumors

  • Cranopharyngioma

  • Other rare brain tumors

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PAEDIATRIC SOLID TUMOURS

  • Neuroblastoma

  • WIlms tumor and renal sarcomas

  • Rhabdomyosarcoma

  • Osteosarcoma

Patient-derived organoids (PDO)

  • Breast carcinoma

  • Colorectal carcinoma

  • Pancreatic ductal carcinoma

  • Cholangiocarcinoma

  • Gallbladder carcinoma

Research Highlights

Disclaimer

All listed tumor models are property of the Cancer Discovery Hub and/or the respective contributing research groups. These models are strictly not be transferred out of the research premises without prior written permission, and are strictly for research use only. 

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