Patient-derived Models of Asian Cancers (PMAC)

Patient-derived tumor models are valuable tools for cancer research, and may particularly useful for pharmaceutical research and drug development. The Cancer Discovery Hub at the National Cancer Centre Singapore hosts a large catalogue of various tumor models ranging from xenografts to cell-lines, mostly derived from patients of Asian ethnicity. Novel models including organoids are also available for customised purposes.

All models listed have been verified histopathologically. Additional verification with genomic profiling have been performed for selected models.

These models are property of contributing research groups, including:

  • Cancer Discovery Hub, NCCS

  • Laboratory of Molecular Endocrinology, NCCS

  • Laboratory of Cancer Epigenome, NCCS

  • Lymphoma Translational Genomics Laboratory, NCCS

  • Laboratory of Applied Human Genetics, NCCS

  • VIVA-KKH Paediatric Solid Tumour Research Laboratory

Contact us if you are interested to use these models for pharmacological drug evaluation, research collaboration, or if you woud like to contribute your tumor models in this catalogue.

Patient-derived xenografts (PDX)

CARCINOMA

  • Hepatocellular carcinoma: >110 models

  • Gastric carcinoma: 34 models

  • Ovarian carcinoma: 35 models including serous, clear cell, mucinous, endometrioid and others

  • Renal cell carcinoma: 18 models including clear cell, papillary and others

  • Lung carcinoma: 8 models including small cell carcinoma and adenocarcinoma

  • Colorectal carcinoma: 8 models

  • Pancreatic carcinoma: 7 models

  • Breast carcinoma: 4 models

 

LYMPHOMA

  • Natural Killer/T-cell lymphoma (NKTCL)

  • Peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS)

  • Monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL)

  • Diffuse large B-cell lymphoma, non-germinal centre (DLBCL)

  • Mantle cell lymphoma, blastoid variant (MCL)

  • Angioimmunoblastic T-cell lymphoma (AITL)

 

SARCOMA & RARE CANCERS

  • Gastrointestinal stromal tumor: 10 models

  • Malignant phyllodes tumor: 4 models

  • Fibrosarcoma

  • Ewing sarcoma

ASCITES-DEPENDENT XENOGRAFTS

  • Colorectal carcinoma: 5 models

  • Ovarian carcinoma: 2 models

  • Melanoma

  • Mesothelioma

PAEDIATRIC CANCERS

  • Neuroblastoma

  • Wilms tumor and renal sarcomas

  • Hepatoblastoma

  • Rhabdomyosarcoma and non-rhabdomyosarcoma soft tissue sarcomas (NRSTS)

  • Osteosarcoma

  • Germ cell tumor and sex cord stromal tumors

Patient-derived cell-lines (PDC)

CARCINOMA

  • Renal cell carcinoma, clear cell: >10 models

  • Renal cell carcinoma, papillary

  • Colorectal carcinoma: > 5 models

  • Ovarian carcinoma: 2 models

LYMPHOMA

  • Natural Killer/T-cell lymphoma (NKTCL)

  • Diffuse large B-cell lymphoma (DLBCL)

  • Burkitt lymphoma (BL)

SARCOMA & RARE CANCERS

  • Malignant phyllodes tumor: 5 models

  • Angiosarcoma: 3 models

  • Gastrointestinal stromal tumor: 2 models

  • Solitary fibrous tumor (SFT)

  • Leiomyosarcoma (LMS)

  • Undifferentiated pleomorphic sarcoma (UPS)

  • Myxofibrosarcoma

  • Mesothelioma: 2 models

  • Melanoma

PAEDIATRIC BRAIN TUMORS

  • Glioma

  • Embryonal tumors

  • Cranopharyngioma

  • Other rare brain tumors

PAEDIATRIC SOLID TUMOURS

  • Neuroblastoma

  • WIlms tumor and renal sarcomas

  • Rhabdomyosarcoma

  • Osteosarcoma

Patient-derived organoids (PDO)

Coming soon

Research Highlights

Disclaimer

All listed tumor models are property of the Cancer Discovery Hub and/or the respective contributing research groups. These models are strictly not be transferred out of the research premises without prior written permission, and are strictly for research use only.