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Patient-derived Models of Asian Cancers (PMAC)

Patient-derived tumor models are valuable tools for cancer research, and may particularly useful for pharmaceutical research and drug development. The Cancer Discovery Hub at the National Cancer Centre Singapore hosts a large catalogue of various tumor models ranging from xenografts to cell-lines, mostly derived from patients of Asian ethnicity. Novel models including organoids are also available for customised purposes.

All models listed have been verified histopathologically. Additional verification with genomic profiling have been performed for selected models.

These models are property of contributing research groups, including:

  • Cancer Discovery Hub, NCCS

  • Laboratory of Molecular Endocrinology, NCCS

  • Laboratory of Cancer Epigenome, NCCS

  • Lymphoma Translational Genomics Laboratory, NCCS

  • Laboratory of Applied Human Genetics, NCCS

  • VIVA-KKH Paediatric Solid Tumour Research Laboratory

Contact us if you are interested to use these models for pharmacological drug evaluation, research collaboration, or if you woud like to contribute your tumor models in this catalogue.

Patient-derived xenografts (PDX)


  • Hepatocellular carcinoma: >110 models

  • Gastric carcinoma: 34 models

  • Ovarian carcinoma: 35 models including serous, clear cell, mucinous, endometrioid and others

  • Renal cell carcinoma: 18 models including clear cell, papillary and others

  • Lung carcinoma: 8 models including small cell carcinoma and adenocarcinoma

  • Colorectal carcinoma: 8 models

  • Pancreatic carcinoma: 7 models

  • Breast carcinoma: 4 models



  • Natural Killer/T-cell lymphoma (NKTCL)

  • Peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS)

  • Monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL)

  • Diffuse large B-cell lymphoma, non-germinal centre (DLBCL)

  • Mantle cell lymphoma, blastoid variant (MCL)

  • Angioimmunoblastic T-cell lymphoma (AITL)



  • Gastrointestinal stromal tumor: 2 models

  • Malignant phyllodes tumor: 4 models

  • Fibrosarcoma

  • Ewing sarcoma


  • Colorectal carcinoma: 5 models

  • Ovarian carcinoma: 2 models

  • Melanoma

  • Mesothelioma


  • Neuroblastoma

  • Wilms tumor and renal sarcomas

  • Hepatoblastoma

  • Rhabdomyosarcoma and non-rhabdomyosarcoma soft tissue sarcomas (NRSTS)

  • Osteosarcoma

  • Germ cell tumor and sex cord stromal tumors

Patient-derived cell-lines (PDC)


  • Renal cell carcinoma, clear cell: >10 models

  • Renal cell carcinoma, papillary

  • Colorectal carcinoma: > 5 models

  • Ovarian carcinoma: 2 models


  • Natural Killer/T-cell lymphoma (NKTCL)

  • Anaplastic Large cell lymphoma (ALCL)

  • Cutaneous T-cell lymphoma (CTCL)

  • Peripheral T-cell lymphoma, NOS (PTCL-NOS)

  • Diffuse large B-cell lymphoma (DLBCL)

  • Burkitt lymphoma (BL)


  • Malignant phyllodes tumor: 5 models

  • Angiosarcoma: 3 models

  • Gastrointestinal stromal tumor: 2 models

  • Dermatofibrosarcoma protuberans/fibrosarcoma (DFSP/FS)

  • Solitary fibrous tumor (SFT)

  • Leiomyosarcoma (LMS)

  • Undifferentiated pleomorphic sarcoma (UPS)

  • Myxofibrosarcoma

  • Mesothelioma: 2 models

  • Melanoma


  • Glioma

  • Embryonal tumors

  • Cranopharyngioma

  • Other rare brain tumors


  • Neuroblastoma

  • WIlms tumor and renal sarcomas

  • Rhabdomyosarcoma

  • Osteosarcoma

Patient-derived organoids (PDO)

  • Breast carcinoma

  • Colorectal carcinoma

  • Pancreatic ductal carcinoma

  • Cholangiocarcinoma

  • Gallbladder carcinoma

Research Highlights


All listed tumor models are property of the Cancer Discovery Hub and/or the respective contributing research groups. These models are strictly not be transferred out of the research premises without prior written permission, and are strictly for research use only. 

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